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Abstract #1751

Spiral-CEST Encoding with Spectral and Spatial B0 Correction

Sugil Kim 1,2 and Jaeseok Park 3

1 Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea, 2 Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Sungkyunkwan University, Suwon, Korea, 3 Biomedical Imaging and Engineering Lab., Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon, Korea

Chemical exchange saturation transfer (CEST), which exploits saturation transfer induced proton exchange and its corresponding, indirect loss of water signals, has been shown to provide a novel contrast mechanism in MRI [1,2]. However, CEST MRI is highly vulnerable to magnetic field inhomogeneities. To address this problem, it often requires multi-spectral acquisitions (z-spectrum), and hence leads to prohibitively long imaging time [3]. In this work, we propose Spiral-CEST encoding with spectral and spatial B0 correction under the hypothesis that in the presence of magnetic field inhomogeneities spiral encoding induced image blurring in the spatial dimension makes no contribution to a DC frequency shift in the z-spectral dimension due to the spatially, slowly varying field map.

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