Abstract #1895
Enriching Fluorine Nanoparticles with Saturated Phosphoethanolamines to Improve Dendritic Cell Detection by 19 F Magnetic Resonance In Vivo
Sonia Waiczies 1 , Stefano Lepore 1 , Min-Chi Ku 1 , Helmar Waiczies 1,2 , Conrad Martin 1 , Susanne Drechsler 1 , Karl Sydow 3 , Margitta Dathe 3 , Andreas Pohlmann 1 , and Thoralf Niendorf 1
1
Berlin Ultrahigh Field Facility (B.U.F.F.),
Max Delbrck Center for Molecular Medicine, Berlin,
Germany, Germany,
2
MRI.Tools
GmbH, Berlin, Germany,
3
Leibniz-Institut
fr Molekulare Pharmakologie, Berlin, Germany
Magnetic resonance (MR) methods to detect and quantify
fluorine nuclei provide the opportunity to study the
fate of cellular transplants in vivo. Challenges
pertaining to MR signal sensitivity and cell detection
exist. This study addresses these issues by examining
the uptake mediating potential of nanoparticles enriched
with phosphatidylethanolamines to improve dendritic cell
detection.
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