Abstract #1898
Vesicles assembled from new dendrimeric amphiphiles and their applicative potential as MRI-based theranostic nanocarriers
Miriam Filippi 1 , Deyssy Patrucco 1 , Jonathan Martinelli 2 , Lorenzo Tei 2 , Mauro Botta 2 , and Enzo Terreno 1,3
1
Department of Molecular Biotechnology and
Health Sciences, Molecular Imaging Center, University of
Turin, Turin, To, Italy,
2
Department
of Sciences and Technological Innovation, University of
Eastern Piedmont 'A. Avogadro', Alessandria, Al, Italy,
3
Center
for Preclinical Imaging, University of Turin, Colleretto
Giacosa, To, Italy
Vesicles composed of newly synthesized amphiphilic
dendrimers were investigated to understand their
effective applicative potential as theranostic tools,
based on their biocompatibility, stability in biological
environments and capability to encapsulate Magnetic
Resonance Imaging (MRI) agents and drugs. Dendrimeric
vesicles revealed to be extremely safe and appropriate
for vascular administration, besides displaying a very
high membrane water permeability, preserving the
Longitudinal Relaxivity of encapsulated paramagnetic MRI
probes from undesired quenching effects. Specifically,
3,5-C12-EG-(OH)4based vesicles were provided with
highest stability, becoming interesting candidates for
further development as theranostic tools.
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