Improved liposomes-based Ca(II) responsive MRI contrast agents
Francesca Garello 1 , Sandip Vibhute 2 , Serhat Gunduz 2 , Nikos K Logothetis 2 , Goran Angelovski 2 , and Enzo Terreno 1
University of Torino, Torino, Italy,
Planck Institute for Biological Cybernetics, Tbingen,
This contribution reports a methodology that enables the
preparation of paramagnetic liposomes loaded with an
amphiphilic ligand capable to coordinate selectively and
sequentially Gd(III) and Ca(II) ions, respectively. The
presence of Gd(III) imparts the ability to generate MRI
contrast, which is remarkably boosted (ca. 400%) by the
coordination of Ca(II), thus improving the calcium
responsiveness of the nanoprobes with respect similar
agents previously investigated.
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