Abstract #1956
Quantification of Individual and Group Uncertainty of Gamma-aminobutyric Acid Concentration in Different Brain Regions Using Residual Bootstrap Analysis
Song Chen 1 , Meng Chen 1 , Congyu Liao 1 , Linfei Wen 1 , Darong Zhu 2 , Xu Yan 3 , Keith Heberlein 4 , and Jianhui Zhong 1
1
Center for Brain Imaging Science and
Technology, Department of Biomedical Engineering,
Zhejiang University, Hangzhou, Zhejiang, China,
2
Hangzhou
First People's Hospital, Hangzhou, Zhejiang, China,
3
MR
Collaboration NE Asia, Siemens Healthcare, Shanghai,
China,
4
Siemens
Medical Solutions USA, Inc, Malvern, PA, United States
Gamma-aminobutyric acid (GABA) is one of important
inhibitory neurotransmitters, closely related to mental
illness such as depression and schizophrenia.
MEGA-PRESS, a spectral editing technique in MRS, is a
non-invasive method for detecting GABA concentration in
vivo. In this study, data from volunteers was acquired
using a robust prototype with MEGA-PRESS pulse sequence,
and the residual bootstrap analysis was used to assess
uncertainty in different regions, variability from
repeated scans, and natural variation among different
subjects.
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