Editing efficiency for macromolecule-suppressed and unsuppressed J-edited GABA spectroscopy
Georg Oeltzschner 1,2 and Pallab K. Bhattacharyya 3,4
Department of Diagnostic and Interventional
Radiology, Medical Faculty, University Dusseldorf,
of Clinical Neuroscience and Medical Psychology, Medical
Faculty, Heinrich-Heine-University Dsseldorf,
Institute, Cleveland Clinic, Cleveland, OH, United
Clinic Lerner College of Medicine - CWRU, Cleveland, OH,
Editing efficiency (EE) of J-edited GABA spectroscopy is
an important parameter for GABA quantification.
Different methods of calculating EE were applied to
spectra from a GABA phantom, including a macromolecule
(MM) suppressed and a MM unsuppressed editing scheme. It
was found that EE may exceed the expected maximum of 0.5
which can be attributed to the central peak of the 3.01
ppm GABA resonance. Size and shape of the central peak
are shown to differ across editing schemes. Simulation
of J-edited spectra indicate that this effect is driven
by the OFF-resonance spectra, suggesting peak shape and
size are influenced by the set of editing frequencies
and sequence properties.
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