Resolution-enhanced MRS of red bone marrow fat via intermolecular double-quantum coherences in human knees
Jianfeng Bao 1,2 , Yuchuan Zhuang 1 , Yanqin Lin 2 , Zhong Chen 2 , and Jianhui Zhong 1
University of Rochester, Rochester, NY,
University, Xiamen, Fujian, China
Trabecular bone structure leads to serious local
inhomogeneous B0 field, rendering it difficult to obtain
high resolution fatty acid MRS in red bone marrow.
Although intermolecular double-quantum coherences (iDQC)
2D MRS has been shown to overcome macroscopic
inhomogeneity induced by biological tissues, this
advantage has not been studied in red bone marrow in
humans. In this study, a localized module iDQC was used
to obtain high resolution fatty acid spectra on red bone
marrow in human knee on a 3.0 T human scanner. This
technique has potential in providing new biomarker
information for diagnosis purposes.
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