The Relationship between Level of Consciousness and Variability of Brain Connectivity
Christina Hamilton 1 , Yuncong Ma 1 , and Pablo Perez 1
Pennsylvania State University, State
College, PA, United States
Anesthesia is an altered state of consciousness that can
be characterized by a complex interaction between an
individuals level of arousal and awareness.
Resting-state functional magnetic resonance imaging
(rsfMRI) has been shown to be a useful tool for
investigating systems-level changes in functional brain
connectivity during anesthesia-induced unconsciousness
(AIU). Here we use rsfMRI and behavioral measures of
anesthetic depth to investigate the dose-dependent
effect of isoflurane on functional brain connectivity.
These findings provide insight into the relationship
between neuroimaging data and behavioral measures of
anesthetic depth, which may provide us with a better
understanding of the neural basis of AIU.
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