Abstract #2082
Modulation of functional connectivity during finger tapping and resting state in patients with MS
Xiaopeng Zhou 1 , Katherine A Koenig 1 , Erik B Beall 1 , Lael Stone 1 , Robert Bermel 1 , Michael D Phillips 1 , and Mark J Lowe 1
1
The Cleveland Clinic, Cleveland, Ohio,
United States
We investigated the modulation of motor connectivity in
patients with multiple sclerosis (MS) and controls by
acquiring fc in 3 conditions (rest, 2 Hz paced finger
tapping and self-paced complex finger
tapping).Significant fc changes in some brain regions
during 2 motor tasks from rs were exhibited, showing fc
network can be modulated under different states in
controls and patients with MS. There was decreased fc in
certain regions of patient compared with controls. The
observation that more group differences were observed in
the resting state suggests that this may be the most
effective way of studying functional impairment in MS.
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