Map the light-driven fMRI signal in combination with in vivo recording
Maosen Wang 1 , Yi He 1 , Yaohui Tang 1 , Dvid Zsolt Balla 2 , Chunqi Qian 3 , and Xin Yu 1
Research Group of Translational Neuroimaging
and Neural Conteol,High Field Magnetic Resonance, Max
Planck Institute for Biological Cybernetics, Tuebingen,
of Physiology of Cognitive Processes, Max Planck
Institute for Biological Cybernetics, Tuebingen,
Functional and Molecular Imaging, National Institute of
Neurological Disorders and Str, National Institutes of
Health, Bethesda, MD, United States
It remains ambiguous how the direct fiber optic
insertion affects the local fMRI signal by optical
stimulation. The fiber optic was inserted to target the
deep layer cortex expressing Channelrhodopsin 2(ChR2).
Robust fMRI signal was detected in the cortical regions
close to the fiber tip with varied light pulse
parameters on frequency, pulse duration and power level.
The light evoked local field potential was also recorded
by electrodes inserted into the cortex expressing ChR2.
This work provides us a robust light-driven fMRI
platform in combination with in vivo recording, which
will facilitate the study to decipher cellular
contribution to fMRI signal from the local neurovascular
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