The susceptibility of dissolved oxygen
Avery J.L. Berman 1,2 , Yuhan Ma 1 , Richard D. Hoge 1,3 , and G. Bruce Pike 1,2
Montreal Neurological Institute, McGill
University, Montreal, Quebec, Canada,
of Radiology/Hotchkiss Brain Institute, University of
Calgary, Calgary, Alberta, Canada,
de neuroimagerie fonctionelle, Centre de recherche de
l'institut de griatrie de Montral, Montreal, Quebec,
The susceptibility of dissolved O
blood was studied, focusing on the implications for BOLD
imaging using hyperoxia. We proposed a model for the
susceptibility of blood that incorporates dissolved O
compared it with another previously proposed model.
Distilled water and samples of bovine plasma were
oxygenated and their susceptibilities were determined
using gradient echo phase imaging. Measured changes in
susceptibility vs. O
were linear, with slopes that were dramatically less
than previously predicted and in good agreement with our
model. Under most physiological conditions, the
susceptibility of dissolved O
be disregarded in MRI studies employing hyperoxia.
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