Abstract #2145
Detection of subtle hypoxic-ischemic injury by oscillating gradient diffusion MRI in neonatal mouse brain
Dan Wu 1 , Frances J Northington 2 , Lee J Martin 3 , and Jiangyang Zhang 4
1
Biomedical Engineering, Johns Hopkins
University School of Medicine, BALTIMORE, Maryland,
United States,
2
Pediatrics,
Johns Hopkins University School of Medicine, Maryland,
United States,
3
Neuroscience,
Johns Hopkins University School of Medicine, Maryland,
United States,
4
Radiology,
Johns Hopkins University School of Medicine, Maryland,
United States
The oscillating gradient diffusion MRI (OGSE) is useful
in probing restricted diffusion in short-diffusion time,
and thus is sensitive to microstructural changes in
small scales. We used OGSE (50-200Hz) to examine
hypoxic-ischemic (HI) injury in neonatal mouse brains at
3hrs and 24hrs after injury. Compared to PGSE, OGSE
results revealed elevated ADC in external capsule in
mild injury mice at 3hrs post-HI, and expanded lesion
areas around the external capsule at 24hrs post-HI. The
enhanced edema contrast in OGSE-ADC maps may correlate
with microstructural pathology in astrocytes as shown in
histology.
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