Abstract #2146
Assessment of Blood Brain Barrier Permeability in the Rat Brain with Ischemic Occlusion Using DSC-MRI
Ramesh Paudyal 1 , Silun Wang 1 , Yonggang Li 2 , Byron D Ford 2 , and Xiaodong Zhang 1
1
Yerkes Imaging Center, Yerkes Regional
Primate Research Center, Emory University, Atlanta, GA,
United States,
2
Neurobiology,
Neurosciences Institute, Morehouse School of Medicine,
Atlanta, GA, United States
The aim of this study was to assess the blood brain
barrier permeability in a rat stroke model induced by a
permanent middle cerebral artery occlusion (i.e., pMCAo)
using dynamic susceptibility contrast-MRI at 48 hr. Our
findings demonstrated that a leakage corrected blood
volume indicated the disruption of BBB in ischemic
injury at 48 hr.
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