Abstract #2234
Tensor-Based Morphometry reveals structural differences between Down syndrome and Alzheimers disease mouse model brains
Nick M Powell 1,2 , Holly E Holmes 2 , Da Ma 1,2 , Marc Modat 1 , Jorge Cardoso 1 , Frances K Wiseman 3 , Victor LJ Tybulewicz 4 , Elizabeth MC Fisher 3 , Mark F Lythgoe 2 , and Sebastien Ourselin 1
1
Centre for Medical Image Computing,
University College London, London, England, United
Kingdom,
2
Centre
for Advanced Biomedical Imaging, University College
London, London, United Kingdom,
3
Department
of Neurodegenerative Disease, Institute of Neurology,
University College London, London, United Kingdom,
4
MRC
National Institute for Medical Research, London, United
Kingdom
We applied optimised protocols for high-resolution ex
vivo MRI phenotyping of mouse brains, together with a
fully automated image processing software pipeline, to
perform tensor-based morphometry (TBM) on individual
mouse models of Down syndrome and Alzheimers disease
(the Tc1 and J20 models, respectively), as well as
Tc1/J20 double mutants. In a comparison between Tc1/J20
and J20 brains, our analysis revealed significant
differences in local morphology (volume) throughout the
brain, including within the thalamus, olfactory bulbs
and cerebellum. Our analysis highlights potential
regions for later histology, and may inform behavioural
investigations.
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