Abstract #2270
DCE-MRI reveals increased peritumoral fluid flow in brain metastases after SRS
Tord Hompland 1 , Catherine Coolens 1 , Brandon Driscoll 1 , Warren Foltz 1 , Cynthia Menard 1 , David A. Jaffray 1,2 , and Caroline Chung 1
1
Princess Margaret Cancer Centre, Toronto,
Ontario, Canada,
2
TECHNA
Institute/University Health Network, ontario, Canada
Here we communicate a method for measuring interstitial
fluid flow in brain metastases, a potential tool to
noninvasively measure changes in IFP. With this method
we were able to show an increased peritumoral fluid flow
2 days following stereotactic surgery, most likely
caused by an increase in tumor vasculature permeability
and subsequent increase in IFP. Interstitial fluid flow
also correlated with peritumoral edema. Interestingly,
we also show that the fluid flow induced contrast agent
transport can lead to misinterpretations of tumor volume
measured by DCE-MRI depending on the time interval
between injection and contrast-enhanced image
acquisition.
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