Cell Size Imaging
Natenael B Semmineh 1 , Ashley M Stokes 1 , John C Gore 1 , and C Chad Quarles 1
Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States
Recently, we demonstrated that T2* and T2 weighted
contrast enhanced MRI signals, when acquired at contrast
agent equilibrium, are predominantly influenced by the
cellular properties of tissue. We now propose a novel
imaging approach that utilizes these T2* and T2 effects
to derive an estimate of mean cell size in a voxel.
Using simulations, in vitro and in vivo studies we
demonstrate that the ratio of ΔR2* and ΔR2 is related to
cellular size and may be used to estimate mean cell size
in a voxel.
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