Dual temporal resolution DCE-MRI reveals increased blood-brain barrier leakage in cerebral small vessel disease
Sau May Wong 1 , Eleana Zhang 2 , Harm J. van de Haar 1 , Julie E.A. Staals 2 , Ccile R.L.P.N. Jeukens 1 , Paul A.M. Hofman 1 , Robert J. van Oostenbrugge 2 , Jacobus F.A. Jansen 1 , and Walter H. Backes 1
Radiology, Maastricht University Medical
Center, Maastricht, Limburg, Netherlands,
Maastricht University Medical Center, Maastricht,
Cerebral small vessel disease(cSVD) affects the small
vessels in the brain, which can potentially lead to
ischemic stroke and dementia. The blood-brain barrier
(BBB) permeability is expected to play a pivotal role in
the pathophysiology. We performed dual temporal
resolution DCE-MRI to quantify BBB permeability.
Significant higher permeability was found for cSVD
patients compared with controls in the normal appearing
brain tissue, which suggests that these regions might be
at risk for further transition into white matter
hyperintensities. Longitudinal studies can now be
initiated to investigate the role of increased BBB
permeability in the course of cSVD.
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