Abstract #2363
Effect of ketamine and isoflurane anesthesia on regional cerebral blood flow of macaque monkeys
Chun-Xia Li 1 , Doty Kempf 1 , Leonard Howell 1 , and Xiaodong Zhang 1
1
Yerkes Imaging Center, Yerkes National
Primate Research Center, Emory University, Atlanta, GA,
United States
Ketamine and isoflurane are widely used for maintaining
general anesthesia and induce a global CBF increase in
humans and animals. However, it is not clear how
differently the CBF is affected between the anesthetics.
In the present study, adult rhesus monkeys were used to
examine the effects of ketamine and isoflurane on CBF
using the continuous arterial spin-labeling (CASL)
perfusion MRI. The present study revealed the different
effects of ketamine and isoflurane on CBF in monkeys
under maintenance doses, suggesting the use of ketamine
or isoflurane might interfere with the experimental
outcome in neurovascular diseases and brain function
studies.
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