A Novel Framework for Unified Analysis of In-vivo and Ex-vivo Cardiac Data Using an In-vivo MRI-derived 3D Printed Model: Application to Cardiac MRI
Sbastien Roujol 1 , Cory Tschabrunn 1 , Tamer A. Basha 1 , Kraig V. Kissinger 1 , Warren J. Manning 1,2 , Mark E. Josephson 1 , Elad Anter 1 , and Reza Nezafat 1
Department of Medicine, Beth Israel
Deaconess Medical Center and Harvard Medical School,
Boston, Massachusetts, United States,
of Radiology, Beth Israel Deaconess Medical Center and
Harvard Medical School, Boston, Massachusetts, United
A variety of animal models have been used in cardiac MRI
(CMR) studies to help characterize the underlying
mechanisms of several cardiomyopathies1. In-vivo and
ex-vivo CMR often provide complementary information.
In-vivo CMR can be used for hemodynamic, functional and
viability evaluation while ex-vivo CMR can provide
structural information with high resolution due to the
absence of physiological motion. The combination of this
information is however challenging since the excised
heart generally shows substantial variations in shape,
when compared to the same in-vivo heart. In this study,
we sought to investigate the feasibility of integrating
a 3D printed model of the in-vivo LV cavity into the
ex-vivo heart to enable imaging of similar LV shape
during in-vivo and ex-vivo CMR.
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