Abstract #2581
Biomimetic Phantom for Cardiac Diffusion Magnetic Resonance Imaging
Irvin Teh 1 , Penny L Hubbard Cristinacce 2,3 , Feng-Lei Zhou 2,4 , Geoffrey JM Parker 2,3 , and Jrgen E Schneider 1
1
Division of Cardiovascular Medicine,
Radcliffe Department of Medicine, University of Oxford,
Oxford, United Kingdom,
2
Centre
for Imaging Sciences, Manchester Academic Health
Sciences Centre, The University of Manchester,
Manchester, United Kingdom,
3
Biomedical
Imaging Institute, The University of Manchester,
Manchester, United Kingdom,
4
The
School of Materials, The University of Manchester,
Manchester, United Kingdom
There is increasing demand for phantoms to aid methods
development in diffusion MRI, and to improve quality
assurance of data. With the majority of phantoms
designed to simulate brain tissue, we have designed a
novel phantom, based on co-electrospinning, to simulate
diffusion in the heart. The phantom was scanned with DTI
over four weeks, and the average mean ADC and FA of 0.76
0.02 x 10
-3
mm
2
/s
and 0.38 0.02 respectively, coincides with published
ex-vivo preclinical data. Fibre tracking illustrates
clearly the transition in helix angle, from -59 to 53
degrees, from the simulated subepicardium to
subendocardium.
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