Abstract #2649
ENHANCED GLUCOSE OXIDATION HAS NO EFFECT ON HYPERTROPHIC PROGRESSION IN THE ABDOMINAL AORTIC BANDING MODEL OF LEFT VENTRICULAR HYPERTROPHY
Lucia F Giles 1 , Vicky Ball 1 , Carolyn A Carr 1 , Anne-Marie L Seymour 2 , Lydia Le Page 1 , Lucy Ambrose 1 , and Damian J Tyler 1
1
Department of Physiology, Anatomy and
Genetics, University of Oxford, Oxford, Oxfordshire,
United Kingdom,
2
Department
of Biological Sciences, University of Hull, Hull, United
Kingdom
The development of left ventricular hypertrophy is an
independent risk factor in the development of heart
failure and is underpinned by metabolic remodelling.
Reduced coupling between glycolysis and glucose
oxidation has been observed with hypertrophic
development in the abdominal aortic constriction (AC)
rat model. Dichloroacetate (DCA) is a potent activator
of pyruvate dehydrogenase enhancing coupling between
glycolysis and glucose oxidation. AC rats were treated
with DCA following hypertrophic development and cardiac
function and metabolism assessed using cine MRI and
hyperpolarized [
13
C]pyruvate. Despite
increasing glucose oxidation and altering the myocardial
metabolic profile with DCA failed to affect
hypertrophic.
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