MRI PERFUSION DISCRIMINATES STUNNED MYOCARDIUM ADJACENT TO FOCAL INFARCT FROM MICROEMBLIZED INFARCTED MYOCARDIUM
Maythem Saeed 1 , Loi Do 1 , Steven W Hetts 1 , and Mark W Wilson 1
Radiology and Biomedical Imaging, University
of California San Francisco, San Francisco, Ca, United
Myocardial perfusion and function was assessed in
ischemic myocardium with and without microemboli using
MRI and postmortem histomorphometry. Pigs (n=24) served
as controls or were subjected to brief coronary artery
occlusion with and without microemboli. MRI was used at
3 days and 5 weeks to acquire cine and perfusion images.
It was found that perfusion MRI has the ability to
differentiate mildly ischemic from microembolized
ischemic myocardium, while cine MRI demonstrated the
severity of injury at global level. The combination of
cine and perfusion MRI showed persistent myocardial
stunning and perfusion deficits in mildly ischemic
myocardium with minor infarction.
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