Intravoxel Incoherent Motion and Arterial Spin Labeling MRI of Isolated Perfused Hearts
Osama Abdullah 1 , Arnold David Gomez 1 , Samer Merchant 1 , Michael Heidinger 2 , Steven Poelzing 2 , and Edward W Hsu 1
Bioengineering, University of Utah, Salt
Lake City, Utah, United States,
Research and Training Institute, University of Utah,
Utah, United States
Intravoxel incoherent motion (IVIM) was investigated in
an animal model of isolated perfused heart as functions
of myocardial blood flow (MBF) and diffusion encoding
direction. The IVIM-derived mean blood velocity (D*) and
volume fraction (VF) were correlated to independent
measure of MBF using arterial spin labeling. The D* was
faster in the direction parallel than perpendicular to
myofibers at normal inflow pressures. The VF had a
strong dependence on MBF but not myofiber orientation.
Collectively, results indicate that IVIM parameters in
the myocardium depend on microcirculation and myofiber
orientation in consistent fashions with the hearts
known anatomy and circulation physiology.
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