In-vivo measurements of axon radius and density in the corpus callosum using anomalous diffusion from diffusion MRI
Qiang YU 1 , Viktor Vegh 1 , Kieran O'Brien 1,2 , Thorsten Feiweier 3 , and David Reutens 1
Centre for Advanced Imaging, University of
Queensland, Brisbane, Queensland, Australia,
Sector, Siemens Ltd, Brisbane, Queensland, Australia,
Healthcare, Erlangen, Germany
Axon radius and packing density provide information on
the role and performance of white-matter pathways. MRI
researchers have tried to measure axon radius, however,
they assumed the radius of axons follows a gamma
distribution or a single axon radius was considered.
From diffusion-weighted data, we mapped axon radii and
packing density in the corpus callosum by fitting the
parameters of the space fractional Bloch-Torrey
anomalous diffusion model. We were able to calculate
axon radii and packing density without any assumptions
of axon radius. We found the values of axon radii to be
in good agreement with previous findings.
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