Abstract #2771
Reconstruction of size distribution of cellular-sized pores using DWI with clinically applicable gradients
Yaniv Katz 1 , Dan Benjamini 1,2 , Peter J Basser 2 , and Uri Nevo 1
1
Biomedical Engineering, Tel Aviv University,
Ramat Aviv, Tel Aviv, Israel,
2
Eunice
Kennedy Shriver National Institute of Child Health and
Human Development (NICHD), National Institutes of
Health, Bethesda, MD, United States
Here we present our successful accurate estimation of
pore size distributions, with pores sizes of typical
cellular sizes, by the use of clinically applicable
pulsed field gradients. We used a double pulsed field
gradient (dPFG) diffusion weighted imaging scheme, with
analysis that is based on the Multiple Correlation
Function framework. We used a well calibrated phantom
and demonstrate successful reconstruction of
polydisperse distributions, composed of up to 3
different pores radii, with different volume fractions.
These results demonstrate that the q value limit
(size<1/q) can be broken, and biological cellular sizes
can potentially be estimated using a dPFG pulse
sequence.
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