Abstract #2789
Multi-exponential characteristics of acetate diffusion-weighted MRS signal in the in vivo rat brain at 14.1T
Masoumeh Dehghani M. 1 , Nicolas Kunz 2 , Bernard Lanz 1 , and Rolf Gruetter 1,2
1
Laboratory for Functional and Metabolic
Imaging, Ecole Polytechnique Fdrale de Lausanne,
Lausanne, Vaud, Switzerland,
2
Centre
dImagerie Biomdicale, Ecole Polytechnique Fdrale de
Lausanne, Lausanne, Vaud, Switzerland
The aim of this study is to address the diffusion
characteristics of Ace in the rat brain in vivo. The
remarkable sensitivity and spectral resolution of
localized 1H MRS at 14T allowed a precise measurement of
the diffusion properties of NAA and Ace at very high
diffusion weighting The significantly large diffusion of
Ace estimated from monoexponential fitting indicates its
smaller molecule size. Different diffusion
characteristics of Ace in the bi-exponential model at
higher b values indicate different in vivo diffusion
barriers and cellular restrictions compared to NAA and
suggest different intracellular distribution space for
Ace in the rat brain.
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