Differentiating microscopic field inhomogeneity induced relaxation from R 2 and R 2 * relaxations with magnetic field correlation imaging
Chu-Yu Lee 1,2 , Xingju Nie 1,2 , Jens H Jensen 1,2 , Vitria Adisetiyo 1,2 , Qingwei Liu 3 , and Joseph A Helpern 1,2
Department of Radiology and Radiology
Science, Medical University of South Carolina,
Charleston, SC, United States,
for Biomedical Imaging, Medical University of South
Carolina, Charleston, SC, United States,
research, Barrow Neurological Institute, Phoenix, AZ,
In biological tissues, the presence of iron-rich cells,
deoxygenated red blood cells or a paramagnetic agent
generates micron-scale variations of magnetic
susceptibility, resulting in microscopic magnetic field
inhomogeneities (μMFI). Therefore, it is possible to
characterize in vivo tissue properties through
quantifying the μMFI. The relaxation rates R2, R2*, and
R2′ have been previously used to quantify the relaxation
due to μMFI. An alternative approach is magnetic field
correlation (MFC) imaging, where the measured MFC is
closely linked to the μMFI. MFC has been shown to
effectively reflect iron depositions in the brain during
normal aging and disease processes. A prior study
compared MFC, R2, and R2* for cell suspensions with
different Gadolinium (Gd) contrast agent concentrations.
However, the distinction between these measures has not
been investigated with structure-induced variable μMFI.
In this work, we investigate how MFC, R2, R2*, R2′
change in phantoms with distinct μMFI properties.
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