Abstract #3245
Assessment of T1rho Sensitivity to pH and Glucose for Human Brain Imaging at 3T
Nana K. Owusu 1 , Casey P. Johnson 2 , William R. Kearney 2 , John A. Wemmie 3,4 , and Vincent A. Magnotta 2
1
Biomedical Engineering, University of Iowa,
Iowa City, IA, United States,
2
Radiology,
University of Iowa, Iowa City, IA, United States,
3
Psychiatry,
University of Iowa, Iowa City, IA, United States,
4
Veterans
Affairs Medical Center, Iowa City, IA, United States
The sensitivity of T1ρ to pH and glucose concentration
is of great interest for imaging a variety of brain
diseases. However, little work has been done on clinical
imaging systems (≤3T) to assess the sensitivity and
improve the specificity of T1ρ to these metabolic
factors. To address this, we conducted pH and glucose
phantom experiments at 3T. We found that T1ρ, compared
to T2, provides superior sensitivity to pH but not
glucose. These findings suggest that T1ρ may be
sensitive to brain pH dynamics at 3T and that
multi-parametric mapping of T1ρ and T2 may improve
acquisition specificity to pH.
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