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Abstract #3313

iHARPERELLA: an improved method for integrated 3D phase unwrapping and background phase removal

Wei Li 1,2 , Bing Wu 3 , and Chunlei Liu 4,5

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 2 Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 3 GE Healthcare, Beijing, China, 4 Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, 5 Radiology, Duke University, Durham, NC, United States

Quantitative susceptibility mapping requires reliable 3D phase unwrapping and background phase removal. Previously, we have developed a method for integrated 3D phase unwrapping and harmonic background phase removal using Laplacian, namely HARPERELLA. In this study, we introduced an improved version of this HARPERELLA method, which allows more intuitive implementation and more robust suppression of the low frequency background phase. Importantly, it also provides the selection between smooth phase throughout the field of view or intact local phase variations around the veins by choosing between Laplacian-based and path-based phase unwrapping.

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