Abstract #3363
Nuclear Overhauser Enhancement Imaging of Glioblastoma Patients at 7 Tesla: Region Specific Correlation with Diffusion Weighted MRI
Daniel Paech 1 , Sina Burth 1 , Johannes Windschuh 2 , Jan Eric Meissner 2 , Moritz Zaiss 2 , Oliver Eidel 1 , Philipp Kickingereder 1 , Peter Bachert 2 , Wolfgang Wick 3 , Heinz Peter Schlemmer 4 , Ralf Omar Floca 4 , Mark Edward Ladd 2 , Sabine Heiland 1 , Martin Bendszus 1 , and Alexander Radbruch 1
1
Neuroradiology, University Hospital
Heidelberg, Heidelberg, Baden-Wrttemberg, Germany,
2
Department
of Medical Physics in Radiology, German cancer research
center, Baden-Wrttemberg, Germany,
3
Neurooncology,
University Hospital Heidelberg, Heidelberg,
Baden-Wrttemberg, Germany,
4
Department
of Radiology, German cancer research center,
Baden-Wrttemberg, Germany
Nuclear Overhauser Enhancement (NOE) mediated CEST at 7
Tesla has recently turned out to provide additional
information compared to standard MRI. However, the
pathophysiological origin of NOE signal is still under
debate. To evaluate possible contributions of
cellularity and protein content, fifteen newly diagnosed
gliobalstoma patients were enrolled in this study to
perform region specific correlation analysis on NOE
mediated CEST signal and the apparent diffusion
coefficient (ADC). The results indicate that within the
area of T2 edema cellularity might contribute to changes
in the NOE-signal, whereas changes in the enhancing
parts must be due to different origins.
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