Impaired Biophysical Integrity of Default Mode Network in Type 2 Diabetes Revealed by Magnetization Transfer Imaging
Shaolin Yang 1,2 , Minjie Wu 1 , Olusola Ajilore 1 , and Anand Kumar 1
Department of Psychiatry, University of
Illinois at Chicago, Chicago, IL, United States,
of Radiology, University of Illinois at Chicago,
Chicago, IL, United States
Reduced functional connectivity within the brains
default mode network (DMN) and impaired connecting white
matter tracts have been reported in type 2 diabetes
mellitus (T2DM). However, it is unknown whether the DMN
nodal regions themselves are also compromised. In this
study, magnetization transfer (MT) imaging was applied
on twenty T2DM patients and twenty-six healthy controls.
Compared with controls, T2DM patients had significantly
lower MT ratio (MTR) in posterior cingulate cortex
(PCC), while no significant differences in other DMN
regions. Reduced PCC MTR correlated with T2DM-related
clinical measures. The impaired PCC in DMN may provide
insights into neurological pathophysiology of T2DM.
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