Limitations of T2-contrast 3D-Fast Spin Echo Sequences in the Differentiation of Radiation Fibrosis versus Tumor Recurrence
Andrea Vargas 1 , Laurent Milot 2 , Simon Graham 1 , and Philip Beatty 1
Medical Biophysics, University of Toronto,
Toronto, Ontario, Canada,
Research Institute, Toronto, Canada
The use of variable flip angles for 3D fast spin echo
sequences (3DFSE) have shown to alter contrast in
T2-weighted images relative to conventional 2DFSE. While
these alterations of contrast may be minimal in brain
tissues, they can have a great consequences in body
applications that encompass a wide range of T2 values.
In this study we evaluate the performance of current
methods that aim to correct T2-contrast in a cervix
cancer application which has a wide range of T2 values
(35 ms < T2 < 84 ms). We show that the differentiation
between recurrent tumor and radiation fibrosis may be
ambiguous at clinical echo times using 3DFSE.
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