Abstract #3398
Optimization of Magnetization-Prepared Rapid Gradient-Echo (MP-RAGE) Sequence for Neonatal Brain MRI
Lili He 1 , Jinghua Wang 2 , Mark Smith 3 , and Nehal A. Parikh 1,4
1
Center for Perinatal Research, The Research
Institute at Nationwide Children's Hospital, Columbus,
Ohio, United States,
2
Center
for Cognitive and Behavioral Brain Imaging, The Ohio
State University, Columbus, Ohio, United States,
3
Radiology
Department, Nationwide Children's Hospital, Columbus,
Ohio, United States,
4
Department
of Pediatrics, The Ohio State University College of
Medicine, Columbus, Ohio, United States
Three-dimensional T1-weighted sequences such as MP-RAGE
are extremely valuable to evaluate neonatal and infant
brain injury/development. Yet, the lack of complete
myelination and smaller head size results in
comparatively lower quality images as compared to adult
brains. In this study, we consider WM-GM contrast
efficiency as an objective function to optimize neonatal
MP-RAGE parameters under optimal k-space sampling by
means of computer simulation. Quantitative analysis
indicated that WM-GM contrast to noise efficiency of
images acquired with our optimal parameters was 20%
higher than those using parameters recommended by a
published protocol; similarly, mean SNR efficiency was
increased by approximately 150%.
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