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Abstract #3532

Distribution of temperature changes and neurovascular coupling in rat brain following 3,4-methylenedioxymethamphetamine (MDMA,ecstasy) exposure

Daniel Coman 1 , Basavaraju G Sanganahalli 1 , Lihong Jiang 1 , Fahmeed Hyder 1,2 , and Kevin Behar 3

1 Diagnostic Radiology, Yale University, New Haven, Connecticut, United States, 2 Biomedical Engineering, Yale University, New Haven, Connecticut, United States, 3 Psychiatry, Yale University, New Haven, Connecticut, United States

MDMA use results in extreme hyperthermia. Neuroimaging of brain temperature could provide mechanistic insights of MDMA action. We measured spatial distributions of MDMA-induced temperature changes and dynamics in rat cortex using BIRDS with TmDOTMA 4- . MDMA induced a fast and homogenous temperature rise throughout the cortex. The correlation between the cortical and body temperature changes suggest that the heat produced in the body is carried by blood to the brain and contributes partially to cortical temperature increase. MDMA-induced changes in temperature, blood flow, and neuronal activity suggest a lack of neurovascular coupling in the thalamus compared to the cortex.

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