Acute Impact of Antipsychotic Treatment on Patient with Schizophrenia: A tract-based automatic analysis (TBAA) with diffusion spectrum imaging (DSI).
Su-Chun Huang 1 , Chih-Min Liu 2 , Tzung-Jeng Hwang 2 , Hai-Gwo Hwu 2 , Yung-Chin Hsu 1 , Yu-Chun Lo 1 , Yu-Jen Chen 1 , and Wen-Yih Isaac Tseng 1,3
Center for Optoelectronic Biomedicine,
National Taiwan University College of Medicine, Taipei,
of Psychiatry, National Taiwan University Hospital,
Imaging Center, National Taiwan University, Taipei,
In the present study we found that after 4 weeks of
treatment, GFA value was significantly increased in left
SLF II, SLF III, and ML. The increase was not presented
along the whole tract, but limited to discrete segments.
Since all the patients reported reduced severity of
symptoms after treatments, these results suggest that
the medication can modulate the integrity of white
matter tract, and further influence the clinical
symptoms. Notably, all the differences were found in
tracts related of sensory input and integration,
implying that the core pathology of schizophrenia may be
related to sensory integration
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