Abstract #3559
Widespread decrease of fractional anisotropy in never treated schizophrenia patients with disease duration over 5 years
Yuan Xiao 1 , Wei Deng 2 , Huaiqiang Sun 1 , Wenjing Zhang 1 , Li Yao 1 , Jia Liu 1 , Min Wu 1 , Chandan Shah 1 , Qiyong Gong 1 , and Su Lui 1
1
Department of Radiology, West China Hospital
of Sichuan University, Huaxi Magnetic Resonance Research
Ctr., Chengdu, Sichuan, China,
2
Department
of Psychiatry, State Key Laboratory of Biotherapy,
Chengdu, Sichuan, China
Tract-based spatial statistics was employed to
investigate the white matter microstructure alteration
in a rare case of chronic but never-medicated
schizophrenia patients. 26 patients and 28 healthy
controls were recruited in this study. It revealed
widespread decrease of FA in the patients, especially in
anterior thalamic radiation, corticospinal tract,
cingulum (cingulate gyrus), forceps minor, inferior
fronto-occipital fasciculus and superior longitudinal
fasciculus. However, only forceps minor exhibited faster
aging effect than controls suggesting the critical role
of forceps minor in the progressive mechanism of
schizophrenia.
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