Clinical correlations of fornix are disparate in first episode and chronic patients with schizophrenia: A tract-based diffusion spectrum imaging analysis
Yan-Lin Chiu 1,2 , Su-Chun Huang 2 , Chih-Min Liu 3 , Tzung-Jeng Hwang 3 , Hai-Gwo Hwu 3 , Yung-Chin Hsu 2 , Yu-Chun Lo 2 , Yu-Jen Chen 2 , and Wen-Yih Isaac Tseng 2,4
School of Medicine, College of Medicine,
National Taiwan University, Taipei, Taiwan,
for Optoelectronic Biomedicine, National Taiwan
University College of Medicine, Taipei, Taiwan,
of Psychiatry, National Taiwan University Hospital,
Imaging Center, National Taiwan University, Taipei,
In the present study we found that fornix is an
important tract when investigating the white matter
microstructural changes of schizophrenia. Decreased GFA
values of bilateral fornix were found in patients group.
Moreover, the correlations of clinical symptoms and GFA
of fornix showed entirely different patterns between FE
and chronic patients. We hypothesize that the phenomenon
may be a complex interaction of medication-related
changes and natural disease progress. For future works,
we plan to do long term follow-up with detailed
medication history of the patients to ascertain the
effects of antipsychotic medications.
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