Abstract #3604
Perfusion Imaging: Bolus truncation alters penumbral status of acute stroke patients. Using a vascular model reduces this effect
Irene Klrke Mikkelsen 1 , Lars Riisgaard Ribe 1 , and Leif stergaard 1
1
Center for functionally integrative
neuroscience, Aarhus University, Aarhus, Denmark
In acute stroke patients, the penumbra indicates
tissue-at-risk. The corresponding imaging marker is the
mismatch between abnormal regions on perfusion-weighted
images (PWI) and diffusion-weighted images (DWI). The
PWI-abnormality is affected, if imaging duration is too
short to capture the entire passage of contrast agent
through the tissue. We simulated bolus truncation in 73
patients, and found that penumbra would have been
overlooked in 22 patients, had imaging duration been 15s
after peak of the arterial curve. This number reduced
with imaging duration, or if a vascular model for was
used for perfusion-calculation. A BT indicator was
suggested for quality assessment.
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