Abstract #3875
Dynamic Contrast Enhanced MRI Detection of a Central Defect in Clear Cell Renal Cell Carcinoma Correlates with a Tumor Scar and Lower Tumor Proliferation Rate
Yue Zhang 1 , Payal Kapur 2,3 , Qing Yuan 1 , Ananth Madhuranthakam 1,4 , Ingrid Carvo 5 , Sabina Signoretti 5 , Ivan Dimitrov 6 , Yin Xi 1 , Katherine Wicks 1 , Jeffrey Cadeddu 1,3 , Vitaly Margulis 3 , James Brugarolas 7,8 , and Ivan Pedrosa 1,4
1
Radiology, University of Texas Southwestern
Medical Center, Dallas, Texas, United States,
2
Pathology,
University of Texas Southwestern Medical Center, Dallas,
Texas, United States,
3
Urology,
University of Texas Southwestern Medical Center, Dallas,
Texas, United States,
4
Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, Dallas, Texas, United
States,
5
Pathology,
Brigham and Womens Hospital, Boston, Massachusetts,
United States,
6
Philips
Medical Systems, Cleveland, Ohio, United States,
7
Internal
Medicine, University of Texas Southwestern Medical
Center, Dallas, Texas, United States,
8
Developmental
Biology, University of Texas Southwestern Medical
Center, Dallas, Texas, United States
The purpose was to investigate if the central
non-enhancing defect seen commonly on contrast-enhanced
MRI in clear cell renal cell carcinoma (ccRCC)
correlates with coagulation necrosis at histopathology
in the same tumor, a known poor prognostic feature for
these tumors. We found that non-enhancing defects in
ccRCC represent tumor scars instead of coagulative
necrosis. Ki-67 staining revealed significantly lower
cell proliferation rate for RCC with scar than that for
those without scar. We hypothesize that this scar is the
result of rapid enlargement of the tumor leading to a
central infarct and may be formed during a subsequent
reparative phase.
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