Abstract #3876
Measurements of Spontaneous R2* Fluctuations for Acute Hypoxia Detection in Head and Neck Cancer
Rafal Panek 1 , Liam Welsh 1 , Maria A. Schmidt 1 , Kate L. Newbold 1 , Kee Wong 1 , Angela M. Riddell 1 , Dow-Mu Koh 1 , Alex Dunlop 1 , Dualta Mcquaid 1 , Shreerang A. Bhide 1 , Kevin J. Harrington 2 , Christopher M. Nutting 2 , Georgina Hopkinson 3 , Cheryl Richardson 3 , Simon P. Robinson 4 , and Martin O. Leach 1
1
Royal Marsden NHS FT and Institute of Cancer
Research, Sutton, Surrey, United Kingdom,
2
Royal
Marsden NHS FT and Institute of Cancer Research, London,
United Kingdom,
3
Royal
Marsden NHS FT, London, United Kingdom,
4
Institute
of Cancer Research, Sutton, Surrey, United Kingdom
In this study we tested the feasibility of measuring
spontaneous fluctuations in the transverse relaxation
rate, R2*, to identify regions with intermittent
erythrocyte and plasma flow, and hence oscillating
oxygen delivery, in patients with advanced squamous cell
carcinoma of the head and neck. Non-random fluctuations
were detected in parts of lymph nodes with low Ktrans
and R2* values, often in the vicinity, but not in the
centre, of necrotic nodal core, suggesting the presence
of fluctuating blood oxygen levels, which could be
caused by an insufficient or intermittent blood
delivery.
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