Anesthesia level modulate brain activity and connections in Monkey
Zhentao Zuo 1 , Xudong Zhao 1 , Yifan Miao 2 , Shuo Shen 1 , Zuxiang Liu 1 , and Yuanye Ma 1
Chinese Academy of Sciences, Institute of
Biophysics, Beijing, Beijing, China,
Key lab of Brain and Cognitive Science, Institute of
Biophysics, Chinese Academy of Sciences, Beijing,
Resting state-fMRI (rs-fMRI) allows studying aesthesis
status through functional connectivity (FC) and
amplitude low-frequency fluctuation (ALFF), as well as
the mechanisms of different neurological diseases.
Several monkeys scanner with different anesthesia depths
underlying rs-fMRI were scanned to explore the variation
of the monkey brain FC patterns and brain region neuron
fluctuation. We found different drip concentrations will
affect the monkey anesthesia depth. Higher concentration
suppresses more neurons activity and also decreases the
connections between different cerebral hemispheres and
surround regions. It also opened a new method to explore
how the intrinsic network created, and whether the
connectome dependent on the neuron activity.
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