Abstract #3986
MRI Measurements of Regional Ventilation Heterogeneity: Ventilation Defect Clusters
Dante Capaldi 1,2 , Khadija Sheikh 1,2 , Sarah Svenningsen 1,2 , Damien Pike 1,2 , David G McCormack 3 , and Grace Parraga 1,2
1
Imaging Research Laboratories, Robarts
Research Institute, London, Ontario, Canada,
2
Department
of Medical Biophysics, The University of Western
Ontario, London, Ontario, Canada,
3
Division
of Respirology, Department of Medicine, The University
of Western Ontario, London, Ontario, Canada
Hyperpolarized noble gas MRI provides a way to visualize
and regionally measure ventilation heterogeneity using
the ventilation defect percent (VDP), although this
normalized volume does not reflect spatial differences
in subjects with the same VDP. We hypothesized that
regional differences in ventilation heterogeneity are
physiologically relevant, and hence the objective of
this algorithm development project was to develop a way
to spatially quantify ventilation heterogeneity obvious
in thoracic 3He MRI. Preliminary results in COPD and
bronchiectasis subjects with the same VDP showed
spatially different ventilation heterogeneity similar to
LCI measurements in the same subjects.
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