Single Breath-hold, Whole Lung Morphometry with Hyperpolarized 3 He Using Parallel Imaging
Yulin V Chang 1 , James D Quirk 1 , Mario Castro 2 , and Dmitriy A Yablonskiy 1
Radiology, Washington University in St.
Louis, St. Louis, MO, United States,
Washington University in St. Louis, St. Louis, MO,
Although diffusion-based in vivo lung morphometry with
hyperpolarized gases MRI is a powerful tool to study
lung diseases, it is usually performed in a 2D mode with
only a few slices because of the requirement for
repetitive imaging of each slice at different diffusion
gradients. Here we present a 3D imaging method that
employs multi-channel receive coils and parallel imaging
reconstruction techniques. This accelerated imaging
scheme allows whole-lung coverage for in vivo lung
morphometry measurement with improved resolution and
minimum loss of accuracy in a single breath-hold.
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