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Abstract #4149

Near Infrared Optical Tomography at MR resolution: Photo-magnetic Imaging

Alex Luk 1 , Yuting Lin 2 , David Thayer 3 , Seunghoon Ha 4 , and Gultekin Gulsen 1

1 UC Irvine, Irvine, California, United States, 2 Harvard Medical School, Massachusetts, United States, 3 UC Irvine Medical, Irvine, California, United States, 4 UC Irvine, Irvine, california, United States

Diffuse optical imaging is advantageous in enhancing tumor diagnosis by providing functional information but suffers from low resolution. We combined MR thermometry and diffuse optical tomography and built the first prototype photo magnetic imaging system. It provides in-vivo functional information with MR resolution and helps to monitor different optical contrast agents such as Indocyanine green. A finite element based forward simulation of the laser induced temperature change map has been compared with PMI measurements. The forward simulation accurately estimates the temperature tomography collected by MR thermometry. By solving the inverse problem with multiple wavelengths, we will be able to reconstruct MR resolution tomography of different chromophores concentrations.

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