Comparison of Relaxation-Based NMR Methods for Quantifying Bound and Pore Bone Water Fractions
Alan C. Seifert 1 , Suzanne L. Wehrli 2 , and Felix W. Wehrli 1
University of Pennsylvania, Philadelphia,
PA, United States,
Hospital of Philadelphia, Philadelphia, PA, United
Increased cortical porosity is a major cause of the
impaired strength of osteoporotic bone. MicroCT and
gravimetry are accepted methods for validation of
porosity and matrix density, but involve long scan times
and destruction of specimens, respectively. In this
work, we compare several NMR methods for quantification
of bound and pore water (biomarkers for matrix density
and porosity, respectively). T2 fitting of CPMG data at
9.4T outperforms T2* fitting of FIDs at 3T, while 2H IR
at 9.4T performs approximately as well as T2* fitting.
Incorporation of a second T1 dimension yields improved
fidelity for both T2 and T2* fitting.
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