4D Flow MRI for intracranial hemodynamic assessment in Alzheimers Disease
Leonardo A Rivera-Rivera 1 , Patrick Turski 2 , Eric M Schrauben 1 , Phillip Kilgas 1 , Carson Hoffman 1 , Kevin M Johnson 1 , Michael Loecher 1 , Chuck Illingworth 2 , Sterling C Johnson 2 , and Oliver Wieben 1,3
Medical Physics, University of
Wisconsin-Madison, Madison, WI, United States,
University of Wisconsin-Madison, WI, United States,
University of Wisconsin-Madison, WI, United States
Cerebral arteries are often morphologically altered and
dysfunctional in Alzheimers disease. In this study, 4D
flow MRI was used to measure intra-cranial flow
features, particularly mean flow and pulsatility index
in patients with AD, MCI and in healthy controls. We
found a statistically significant decrease in mean flow,
and an increase in pulsatility index for the AD and MCI.
With the large volume coverage and high temporal and
spatial resolution, 4D flow MRI can provide additional
biomarkers of vascular health that can contribute to the
identifying patients who could benefit from
interventions to improve circulatory system functions.
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