Meeting Banner
Abstract #4313

Mean Diffusivity as a non-invasive biomarker of the amount of amyloid plaques in Alzheimers disease: a preliminary evaluation in a mouse model.

Matteo Figini 1 , Alessandro Scotti 1 , Ileana Zucca 1 , Emanuela Maderna 2 , Margherita Ruggerone 2 , Marcella Catania 2 , Giuseppe Di Fede 2 , Fabio Moda 2 , Fabrizio Tagliavini 2 , and Maria Grazia Bruzzone 3

1 Scientific Direction, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Milan, Italy, 2 Neuropathology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy, 3 Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy

In this work, the potential of diffusion MRI (dMRI) parameters in the characterization of neuropathological features of Alzheimers diseases was investigated in a mouse model. Transgenic mice treated with different doses of a synthetic peptide were submitted to 7T dMRI at different time points. A reduction of mean diffusivity was associated with the deposition of amyloid plaques highlighted by immunohistochemistry. If this preliminary result will be confirmed in further works, mean diffusivity may be an in vivo biomarker of the amount of amyloid plaques, with applications in the diagnosis and monitoring of therapy effects on Alzheimers patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here