Abstract #4420
Detecting atrophy in chronic moderate and severe traumatic brain injury using an automated volume-based morphometry toolbox
Yang Wang 1,2 , Benedicte Marechal 3,4 , Dawn Neumann 2 , Alexis Roche 3,4 , John D West 2 , Brenna C McDonald 2 , Michelle A Keiski 2 , Dori J Smith 2 , Andrew J Saykin 2 , and Gunnar Kruger 3,4
1
Medical College of Wisconsin, Milwaukee, WI,
United States,
2
Indiana
University School of Medicine, Indianapolis, IN, United
States,
3
Siemens
Healthcare IM BM PI & Department of Radiology CHUV,
Lausanne, Switzerland,
4
LTS5,
cole Polytechnique Fdrale de Lausanne, Lausanne,
Switzerland
Identification of structural abnormalities in chronic
traumatic brain injury (TBI) remains challenging because
the brain often appears quite normal on conventional CT
and MRI scans. Using an automatic volume-based
morphometry toolbox, we have evaluated atrophy in
chronic moderate and severe TBI that is associated with
severity of cognitive deficit. Our results suggest the
usefulness of this toolbox in clinical settings for fast
volumetric analysis without complex post-processing
steps.
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