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Abstract #4474

Multi-slice Excitation with MRI Tagging for Single Breath hold Estimates of Left Ventricular Rotational Mechanics

Zhe Wang 1,2 , Ziwu Zhou 1,2 , Yi Wang 3 , Peng Hu 1,2 , and Daniel B. Ennis 1,2

1 Radiological Science, University of California, Los Angeles, CA, United States, 2 Bioengineering, University of California, Los Angeles, CA, United States, 3 Neurology, University of California, Los Angeles, CA, United States

Current clinical protocols for measuring LV twist require two separate breath holds to acquire tagged images at the LV apex and LV base, which subjects estimates of LV twist to breath hold differences. Multi-slice excitation (CAIPIRINHA) permits combining these two acquisitions into a single scan. We implemented the CAIPIRINHA technique with a tagging sequence, acquired data in five healthy volunteers, and compare the results with traditional two breath-hold LV twist results. Linear regression shows a high correlation between the two (r=0.99) and LV twist Bland-Altman result shows a small bias of 0.21 with narrow 95% confident intervals of [-0.47, 0.89].

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