Improvement of Left Ventricular Strain with Reduction of Mean Pulmonary Arterial Pressure in Pulmonary Hypertension: Treatment Effect Independent of Right Ventricular Volumetric Parameters.
Tomoyoshi Kimura 1,2 , Hideki Ota 1 , Koichiro Sugimura 3 , Kazuomi Yamanaka 1 , Tatsuo Nagasaka 1 , Hiroaki Shimokawa 3 , Kei Takase 1 , and Haruo Saito 2
Radiology, Tohoku University Hospital,
Sendai, Miyagi, Japan,
School of Medicine, Tohoku University, Sendai, Miyagi,
Tohoku University Hospital, Sendai, Miyagi, Japan
We enrolled 11 patients with chronic thromboembolic
pulmonary hypertension and one with idiopathic pulmonary
arterial hypertension. Biventricular function and left
ventricular (LV) strain analyses were performed before
and after treatment. MR-derived parameters of cardiac
functions were compared with mean pulmonary arterial
pressure (mPAP). All patients demonstrated normal LV
ejection fraction at baseline. Right ventricular (RV)
end-systolic and end-diastolic volume index were
correlated with mPAP at baseline; none of the strain
parameters were correlated. However, improvements of
circumferential and radial strain in inferolateral
segment as well as RV end-systolic volume index were
independently correlated with reduction of mPAP.
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